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Table 4 Association of SUA and all-cause mortality via Cox regression analysis

From: Gender differences in the relationship between serum uric acid and the long-term prognosis in heart failure: a nationwide study

 

Unadjusted model

Adjusted model

 

HR (95% CI)

p value

HR (95% CI)

p value

Whole population (N=1593)

    

Continuous per 1 unit increase

1.15 (1.11-1.19)

<0.001

1.09 (1.05-1.14)

<0.001

Tertile 1 (<5.5 mg/dL)

Reference

--

Reference

--

Tertile 2 (5.6-7.0 mg/dL)

0.96 (0.81-1.14)

0.657

0.94 (0.78-1.12)

0.474

Tertile 3 (>7.0 mg/dL)

1.52 (1.29-1.78)

<0.001

1.28 (1.06-1.54)

0.009

Men (N=897, 56.3%)

    

Continuous per 1 unit increase

1.14 (1.09-1.20)

<0.001

1.11 (1.05-1.18)

<0.001

Tertile 1 (<5.9 mg/dL)

Reference

--

Reference

--

Tertile 2 (5.9-7.4 mg/dL)

0.99 (0.79-1.24)

0.914

1.05 (0.82-1.33)

0.720

Tertile 3 (>7.4 mg/dL)

1.71 (1.38-2.12)

<0.001

1.49 (1.17-1.91)

0.001

Women (N=696, 43.7%)

    

Continuous per 1 unit increase

1.16 (1.10-1.23)

<0.001

1.05 (0.98-1.12)

0.186

Tertile 1 (<5.1 mg/dL)

Reference

--

Reference

--

Tertile 2 (5.1-6.5 mg/dL)

1.28 (0.99-1.67)

0.064

0.97 (0.73-1.28)

0.834

Tertile 3 (>6.5 mg/dL)

1.64 (1.27-2.12)

<0.001

1.03 (0.77-1.39)

0.836

  1. The multivariate Cox regression analysis was adjusted for age, race, diabetes, stroke, drinking history, BMI, diastolic BP, WBC, hemoglobin, albumin, total cholesterol, eGFR, serum potassium, serum sodium, serum chloride, prescription of beta-blockers, prescription of MRA, prescription of diuretics, and prescription of urate-lowering agents
  2. Abbreviation: BMI, body mass index; BP, blood pressure, eGFR, the rate of estimated glomerular filtration rate; WBC, white blood cell; MRA, mineralocorticoid-receptor antagonist; HR, hazard ratio; CI, confidence interval