Table 1 Baseline demographic and clinical characteristics in men

Uric acid (mg/dL)

6.6 (5.4-7.9)

<5.9

5.9-7.4

>7.4

Age, years

70 (61-78)

70 (60-78)

68 (60-77)

70 (61-78)

Body mass index, kg/m²

29.6 (25.9-34.0)

28.1 (24.2-32.3)

30.4 (26.4-34.7) ^†

30.5 (26.4-35.1) ^†

Systolic BP, mmHg

128 (115-142)

128 (116-142)

128 (115-142)

126 (113-144)

Diastolic BP, mmHg

68 (58-78)

69 (58-77)

70 (60-78)

66 (58-77)

Heart rate, bpm

70 (62-78)

70 (60-76)

70 (60-78)

69 (62-78)

Race, n (%)

Non-Hispanic White

522 (58.2)

173 (56.5)

178 (59.5)

171 (58.6)

No-Hispanic Black

179 (20.0)

54 (17.6)

47 (15.7)

78 (26.7) ^†‡

Mexican American

93 (10.4)

37 (12.1)

38 (12.7)

18 (6.2) ^†‡

Other

103 (11.4)

42 (13.8)

36 (12.1)

25 (8.5) ^†

History of smoking, n (%)

643 (71.7)

215 (70.3)

218 (72.9)

210 (71.9)

History of drinking, n (%)

691 (77.0)

227 (74.2)

241 (80.6)

223 (76.4)

Hypertension, n (%)

721 (80.4)

231 (75.5)

241 (80.6)

249 (85.3) ^†

Diabetes mellitus, n (%)

387 (43.1)

134 (43.8)

123 (41.1)

130 (44.5)

Coronary heart disease, n (%)

432 (48.2)

148 (48.4)

153 (51.2)

131 (44.9)

Stroke, n (%)

184 (20.5)

72 (23.5)

54 (18.1)

58 (19.9)

Laboratory tests

WBC, 10³/uL

7.3 (6.1-8.8)

7.3 (6.0-8.5)

7.3 (6.0-8.8)

7.3 (6.1-8.9)

Hemoglobin, g/dL

14.0 (12.5-15.0)

14.1 (12.6-15.1)

14.1 (12.8-15.0)

13.7 (12.1-14.9) ^‡

Albumin, g/L

41.0 (39.0-43.0)

41.0 (38.0-44.0)

41.0 (39.0-43.0)

41.0 (39.0-43.0)

HbA1c, %

5.9 (5.5-6.6)

5.9 (5.4-6.7)

5.9 (5.5-6.5)

6.0 (5.5-6.6)

Total cholesterol, mmol/L

4.3 (3.6-5.1)

4.3 (3.6-5.0)

4.4 (3.6-5.2)

4.4 (3.6-5.3)

Triglycerides, mg/dL

135.0 (91.5-200.5)

128.0 (84.0-192.5)

143.0 (97.0-202.0)

139.0 (95.0-205.8)

Serum glucose, mg/dL

102.0 (92.0-128.0)

102.0 (91.0-135.0)

100.0 (91.0-124.0)

104.0 (93.0-125.0)

eGFR, mL/min/1.73m²

67.5 (50.2-88.2)

76.8 (59.3-94.7)

69.5 (53.3-88.8) ^†

55.8 (40.4-71.2) ^†‡

Serum sodium, mmol/L

139.0 (138.0-141.0)

139.0 (137.0-141.0)

139.0 (138.0-141.0)

139.0 (138.0-141.0)

Serum potassium, mmol/L

4.2 (3.9-4.5)

4.2 (4.0-4.5)

4.1 (3.9-4.4) ^†

4.2 (3.9-4.5) ^‡

Serum chloride, mmol/L

103.0 (100.0-105.0)

103.0 (100.0-105.0)

103.0 (101.0-105.0)

102.0 (100.0-105.0)

Medication

ACEI/ARB, n (%)

504 (56.2)

145 (47.4)

167 (55.9) ^†

192 (65.8) ^†‡

Beta blockers, n (%)

534 (59.5)

169 (55.2)

171 (57.2)

194 (66.4) ^†‡

MRA, n (%)

64 (7.1)

9 (2.9)

19 (6.4) ^†

36 (12.3) ^†‡

Diuretics, n (%)

431 (48.0)

89 (29.1)

135 (45.2) ^†

207 (70.9) ^†‡

Urate-lowering agents, n (%)

78 (8.7)

37 (12.1)

27 (9.0)

14 (4.8) ^†‡