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Table 4 Odds ratios (95% confidence intervals [CIs]) of T2DM combined with atherosclerosis according to tertiles

From: Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

  

Tertiles

1-unit increment of log variables

P value b

T1

T2

T3

P-trend a

FGF23

      

Model 1

1.0 (ref)

1.16 (1.06, 1.27)

1.25 (1.14, 1.38)

< 0.01

1.48 (1.26, 1.73)

< 0.01

Model 2

1.0 (ref)

1.16 (1.06, 1.27)

1.26 (1.15, 1.38)

< 0.01

1.50 (1.28, 1.76)

< 0.01

Model 3

1.0 (ref)

1.10 (1.00, 1.19)

1.19 (1.09, 1.30)

< 0.01

1.34 (1.15, 1.55)

< 0.01

Model 4

1.0 (ref)

1.10 (1.00, 1.20)

1.19 (1.09, 1.30)

< 0.01

1.34 (1.15, 1.55)

< 0.01

α-klotho

      

Model 1

1.0 (ref)

1.03 (0.94, 1.13)

0.93 (0.85, 1.02)

0.14

0.92 (0.82, 1.02)

0.13

Model 2

1.0 (ref)

1.03 (0.94, 1.13)

0.93 (0.85, 1.02)

0.15

0.92 (0.82, 1.03)

0.14

Model 3

1.0 (ref)

1.02 (0.93, 1.11)

0.94 (0.86, 1.01)

0.12

0.91 (0.83, 1.01)

0.08

Model 4

1.0 (ref)

1.02 (0.94, 1.11)

0.94 (0.86, 1.02)

0.13

0.91 (0.83, 1.01)

0.09

FGF23/α-klotho

      

Model 1

1.0 (ref)

1.12 (1.02, 1.22)

1.18 (1.07, 1.29)

< 0.01

1.20 (1.10, 1.32)

< 0.01

Model 2

1.0 (ref)

1.11 (1.01, 1.22)

1.18 (1.07, 1.29)

< 0.01

1.21 (1.10, 1.32)

< 0.01

Model 3

1.0 (ref)

1.08 (0.99, 1.18)

1.13 (1.04, 1.23)

< 0.01

1.16 (1.07, 1.27)

< 0.01

Model 4

1.0 (ref)

1.08 (0.99, 1.18)

1.13 (1.01, 1.23)

< 0.01

1.16 (1.07, 1.27)

< 0.01

  1. Bold font indicates statistical significance
  2. Model 1: adjusted for age and sex
  3. Model 2: based on Model 1, additionally adjusted for smoking status and BMI.
  4. Model 3: based on Model 2, additionally adjusted for SBP, DBP, TC, TG, HDL-c, and LDL-c.
  5. Model 4: based on Model 3, additionally adjusted for eGFR
  6. Abbreviations T2DM, type 2 diabetes mellitus; FGF23, fibroblast growth factor 23; α-klotho, α-membrane binding receptor Klotho
  7. aP-trend was obtained by including the median of each quartile (log10-transformed) of serum FGF23, α-klotho or FGF23/α-klotho ratio as a continuous variable in the logistic regression models
  8. bP value was linear for each 1-unit increase in log10 FGF23, α-klotho or FGF23/α-klotho ratio