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Table 3 Odds ratios (95% confidence intervals [CIs]) of T2DM patients combined with CIMT according to tertiles

From: Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

 

Tertiles

1-unit increment of log variables

P value b

T1

T2

T3

P-trend a

FGF23

      

Model 1

1.0 (ref)

1.50 (1.25, 1.80)

1.75 (1.46, 2.11)

< 0.01

2.72 (2.00, 3.69)

< 0.01

Model 2

1.0 (ref)

1.49 (1.24, 1.79)

1.76 (1.47, 2.12)

< 0.01

2.77 (2.03, 3.77)

< 0.01

Model 3

1.0 (ref)

1.32 (1.12, 1.56)

1.56 (1.32, 1.84)

< 0.01

2.16 (1.62, 2.88)

< 0.01

Model 4

1.0 (ref)

1.32 (1.12, 1.56)

1.56 (1.31, 1.84)

< 0.01

2.16 (1.62, 2.87)

< 0.01

α-klotho

      

Model 1

1.0 (ref)

1.00 (0.83, 1.20)

0.84 (0.70, 1.00)

0.07

0.83 (0.67, 1.03)

0.09

Model 2

1.0 (ref)

1.01 (0.84, 1.21)

0.84 (0.70, 1.01)

0.07

0.84 (0.67, 1.04)

0.10

Model 3

1.0 (ref)

0.99 (0.84, 1.17)

0.85 (0.72, 1.00)

0.06

0.83 (0.68, 1.01)

0.06

Model 4

1.0 (ref)

0.99 (0.84, 1.17)

0.85 (0.73, 1.01)

0.06

0.83 (0.69, 1.01)

0.06

FGF23/α-klotho

      

Model 1

1.0 (ref)

1.34 (1.12, 1.62)

1.50 (1.25, 1.81)

< 0.01

1.56 (1.30, 1.88)

< 0.01

Model 2

1.0 (ref)

1.34 (1.11, 1.61)

1.51 (1.25, 1.81)

< 0.01

1.57 (1.30, 1.88)

< 0.01

Model 3

1.0 (ref)

1.26 (1.07, 1.49)

1.38 (1.17, 1.63)

< 0.01

1.44 (1.22, 1.70)

< 0.01

Model 4

1.0 (ref)

1.26 (1.07, 1.49)

1.38 (1.17, 1.63)

< 0.01

1.44 (1.22, 1.70)

< 0.01

  1. Bold font indicates statistical significance
  2. Model 1: adjusted for age and sex
  3. Model 2: based on Model 1, additionally adjusted for smoking status and BMI.
  4. Model 3: based on Model 2, additionally adjusted for SBP, DBP, TC, TG, HDL-c, and LDL-c.
  5. Model 4: based on Model 3, additionally adjusted for eGFR.
  6. Abbreviations T2DM, type 2 diabetes mellitus; FGF23, fibroblast growth factor 23; α-klotho, α-membrane binding receptor Klotho
  7. aP-trend was obtained by including the median of each quartile (log10-transformed) of serum FGF23, α-klotho or FGF23/α-klotho ratio as a continuous variable in the logistic regression models
  8. bP value was linear for each 1-unit increase in log10 FGF23, α-klotho or FGF23/α-klotho ratio