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Table 2 Odds ratios (95% confidence intervals [CIs]) of T2DM according to tertiles

From: Relationships of serum FGF23 and α-klotho with atherosclerosis in patients with type 2 diabetes mellitus

 

Tertiles

1-unit increment of log variables

P value b

T1

T2

T3

P-trend a

FGF23

      

Model 1

1.0 (ref)

1.42 (1.28, 1.58)

1.69 (1.52, 1.89)

< 0.01

2.52 (2.10, 3.02)

< 0.01

Model 2

1.0 (ref)

1.42 (1.28, 1.59)

1.71 (1.53, 1.90)

< 0.01

2.57 (2.14, 3.08)

< 0.01

Model 3

1.0 (ref)

1.36 (1.23, 1.51)

1.59 (1.43, 1.76)

< 0.01

2.23 (1.87, 2.66)

< 0.01

Model 4

1.0 (ref)

1.36 (1.23, 1.51)

1.59 (1.43, 1.77)

< 0.01

2.23 (1.87, 2.67)

< 0.01

α-klotho

      

Model 1

1.0 (ref)

0.97 (0.86, 1.08)

0.83 (0.75, 0.93)

< 0.01

0.80 (0.71, 0.91)

< 0.01

Model 2

1.0 (ref)

0.97 (0.87, 1.08)

0.84 (0.75, 0.93)

< 0.01

0.81 (0.71, 0.92)

< 0.01

Model 3

1.0 (ref)

0.97 (0.88, 1.08)

0.85 (0.77, 0.94)

< 0.01

0.82 (0.72, 0.92)

< 0.01

Model 4

1.0 (ref)

0.97 (0.88, 1.08)

0.85 (0.77, 0.94)

< 0.01

0.82 (0.72, 0.92)

< 0.01

FGF23/α-klotho

      

Model 1

1.0 (ref)

1.26 (1.12, 1.41)

1.45 (1.29, 1.63)

< 0.01

1.56 (1.40, 1.74)

< 0.01

Model 2

1.0 (ref)

1.26 (1.12, 1.41)

1.45 (1.29, 1.63)

< 0.01

1.56 (1.40, 1.75)

< 0.01

Model 3

1.0 (ref)

1.22 (1.10, 1.36)

1.38 (1.24, 1.54)

< 0.01

1.47 (1.33, 1.64)

< 0.01

Model 4

1.0 (ref)

1.22 (1.10, 1.36)

1.38 (1.24, 1.54)

< 0.01

1.47 (1.33, 1.64)

< 0.01

  1. Bold font indicates statistical significance
  2. Model 1: adjusted for age and sex
  3. Model 2: based on Model 1, additionally adjusted for smoking status and BMI.
  4. Model 3: based on Model 2, additionally adjusted for SBP, DBP, TC, TG, HDL-c, and LDL-c.
  5. Model 4: based on Model 3, additionally adjusted for eGFR.
  6. Abbreviations T2DM, type 2 diabetes mellitus; FGF23, fibroblast growth factor 23; α-klotho, α-membrane binding receptor Klotho
  7. aP-trend was obtained by including the median of each quartile (log10-transformed) of serum FGF23, α-klotho or FGF23/α-klotho ratio as a continuous variable in the logistic regression models
  8. bP value was linear for each 1-unit increase in log10 FGF23, α-klotho or FGF23/α-klotho ratio